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Molecular Profile EML4 - ALK ALK F1174C ALK V1180L
Therapy Alectinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK F1174C ALK V1180L lung adenocarcinoma predicted - resistant Alectinib Case Reports/Case Series Actionable In a clinical case study, a patient with lung adenocarcinoma harboring EML4-ALK (e6:e20) and ALK F1174C progressed on treatment with Alecensa (alectinib) and was found to have acquired ALK V1180L (PMID: 38978737). 38978737
PubMed Id Reference Title Details
(38978737) Case report: Precise NGS and combined bevacizumab promote durable response in ALK-positive lung adenocarcinoma with multiple-line ALK-TKI resistance. Full reference...