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| Molecular Profile | FGFR3 S249C FGFR3 V555L |
| Therapy | Fexagratinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 S249C FGFR3 V555L | Advanced Solid Tumor | resistant | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing FGFR3 S249C and V555L was resistant to Fexagratinib (AZD4547) in culture (PMID: 39082679). | 39082679 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39082679) | A Tetravalent Bispecific Antibody Selectively Inhibits Diverse FGFR3 Oncogenic Variants. | Full reference... |