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Molecular Profile | IDH1 R132X |
Therapy | Vorasidenib |
Indication/Tumor Type | astrocytoma, IDH-mutant, grade 2 |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132X | astrocytoma, IDH-mutant, grade 2 | sensitive | Vorasidenib | FDA approved | Actionable | In a Phase III trial l (INDIGO) that supported FDA approval, Voranigo (vorasidenib) treatment significantly improved progression-free survival (27.7 vs 11.1 months, HR 0.39, p<0.001) and time to next intervention (HR 0.26, p<0.001) compared to placebo in adult and pediatric patients 12 years and older with WHO grade 2 astrocytoma or oligodendroglioma harboring susceptible IDH1 or IDH2 mutations, including IDH1 R132H/C/G/L/S (PMID: 37272516; NCT04164901). | detail... 37272516 |
PubMed Id | Reference Title | Details |
---|---|---|
(37272516) | Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. | Full reference... |
Voranigo (vorasidenib) FDA Drug Label | Full reference... |