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Molecular Profile IDH2 R172X
Therapy Vorasidenib
Indication/Tumor Type astrocytoma, IDH-mutant, grade 2
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH2 R172X astrocytoma, IDH-mutant, grade 2 sensitive Vorasidenib FDA approved Actionable In a Phase III trial l (INDIGO) that supported FDA approval, Voranigo (vorasidenib) treatment significantly improved progression-free survival (27.7 vs 11.1 months, HR 0.39, p<0.001) and time to next intervention (HR 0.26, p<0.001) compared to placebo in adult and pediatric patients 12 years and older with WHO grade 2 astrocytoma or oligodendroglioma harboring susceptible IDH1 or IDH2 mutations, including IDH2 R172K/M/W/S/G (PMID: 37272516; NCT04164901). detail... 37272516
PubMed Id Reference Title Details
(37272516) Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. Full reference...
Voranigo (vorasidenib) FDA Drug Label Full reference...