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| Molecular Profile | BRAF V600E |
| Therapy | RGT-018 |
| Indication/Tumor Type | melanoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | melanoma | no benefit | RGT-018 | Preclinical - Cell culture | Actionable | In a preclinical study, RGT-018 did not inhibit proliferation of melanoma cells harboring BRAF V600E in 3D culture (PMID: 39087485). | 39087485 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39087485) | Discovery of RGT-018: a Potent, Selective and Orally Bioavailable SOS1 Inhibitor for KRAS-driven Cancers. | Full reference... |