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Molecular Profile FGFR2 act mut
Therapy Derazantinib
Indication/Tumor Type transitional cell carcinoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 act mut transitional cell carcinoma no benefit Derazantinib Phase Ib/II Actionable In a Phase I/II trial (FIDES-02), Derazantinib (ARQ 087) treatment was well tolerated but demonstrated limited efficacy in patients with urothelial carcinoma harboring FGFR1 (n=4), FGFR2 (n=7), or FGFR3 (n=35) mutations or FGFR3 fusions (n=6), with an objective response rate of 8.2% (4/49, all partial responses) and disease control rate of 30.6% (15/49) by independent central review (PMID: 38627238; NCT04045613). 38627238
PubMed Id Reference Title Details
(38627238) Derazantinib alone and with atezolizumab in metastatic urothelial carcinoma with activating FGFR aberrations. Full reference...