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Molecular Profile | EML4 - ALK ALK I1171N |
Therapy | Alectinib |
Indication/Tumor Type | sarcoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK I1171N | sarcoma | predicted - resistant | Alectinib | Case Reports/Case Series | Actionable | In a Phase II trial, ALK I1171N was identified on post-progression biopsy in a patient with metastatic non-myofibroblastic sarcoma harboring EML4-ALK (e2:e20), who previously achieved a partial response on Alecensa (alectinib) treatment (PMID: 39188081). | 39188081 |
PubMed Id | Reference Title | Details |
---|---|---|
(39188081) | Metastatic Non-Myofibroblastic Sarcoma Harbouring EML4-ALK Fusion-Dramatic Response to ALK Tyrosine Kinase Inhibitors and Development of Resistance Mutations. | Full reference... |