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Molecular Profile | FGFR2 C382R FGFR2 N549D |
Therapy | Futibatinib |
Indication/Tumor Type | intrahepatic cholangiocarcinoma |
Response Type | conflicting |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 C382R FGFR2 N549D | intrahepatic cholangiocarcinoma | conflicting | Futibatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with intrahepatic cholangiocarcinoma harboring FGFR2 C382R (reported as C383R) and FGFR2 N549D (reported as N550D) experienced progressive disease on treatment with Lytgobi (futibatinib), however, treatment in the patient-derived xenograft (PDX) model resulted in tumor growth inhibition (PMID: 39226398). | 39226398 |
PubMed Id | Reference Title | Details |
---|---|---|
(39226398) | Understanding and Overcoming Resistance to Selective FGFR inhibitors Across FGFR2-Driven Malignancies. | Full reference... |