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Molecular Profile FGFR2 C383R FGFR2 N550D
Therapy Lirafugratinib
Indication/Tumor Type intrahepatic cholangiocarcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 C383R FGFR2 N550D intrahepatic cholangiocarcinoma sensitive Lirafugratinib Preclinical - Pdx Actionable In a preclinical study, Lirafugratinib inhibited tumor growth in a patient-derived xenograft (PDX) model of intrahepatic cholangiocarcinoma harboring FGFR2 C383R and FGFR2 N550D (PMID: 39226398). 39226398
PubMed Id Reference Title Details
(39226398) Understanding and Overcoming Resistance to Selective FGFR inhibitors Across FGFR2-Driven Malignancies. Full reference...