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Molecular Profile | BRAF V600E |
Therapy | Cetuximab + Encorafenib |
Indication/Tumor Type | pseudomyxoma peritonei |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | pseudomyxoma peritonei | sensitive | Cetuximab + Encorafenib | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, treatment with the combination of Braftovi (encorafenib) and Erbitux (cetuximab) inhibited viability and induced apoptosis in a patient-derived pseudomyxoma peritonei cell line harboring BRAF V600E in culture and inhibited tumor growth and improved survival of a patient-derived xenograft (PDX) model (PMID: 39018564). | 39018564 |
PubMed Id | Reference Title | Details |
---|---|---|
(39018564) | Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei. | Full reference... |