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Molecular Profile | BRAF fusion |
Therapy | Selumetinib |
Indication/Tumor Type | high grade glioma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF fusion | high grade glioma | predicted - sensitive | Selumetinib | Case Reports/Case Series | Actionable | In a retrospective analysis, Koselugo (selumetinib) treatment resulted in a partial response with a tumor reduction of 52% in a patient with high grade neuroepithelial tumor harboring a BRAF fusion (PMID: 38922339; NCT01775072). | 38922339 |
PubMed Id | Reference Title | Details |
---|---|---|
(38922339) | Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets. | Full reference... |