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Molecular Profile EML4 - ALK ALK E803Q ALK V1180L
Therapy Alectinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK E803Q ALK V1180L lung adenocarcinoma predicted - resistant Alectinib Case Reports/Case Series Actionable In a clinical case study, ALK E803Q and V1180L were identified in post-progression biopsy in a patient with metastatic lung adenocarcinoma harboring EML4-ALK (e6:e20), who previously achieved a partial response on Alecensa (alectinib) treatment (PMID: 39267820). 39267820
PubMed Id Reference Title Details
(39267820) A novel secondary ALK gene mutation which resistant to second-generation TKIs: a case report and literature review. Full reference...