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| Molecular Profile | BTK C481S |
| Therapy | ONO-7018 |
| Indication/Tumor Type | diffuse large B-cell lymphoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481S | diffuse large B-cell lymphoma | predicted - sensitive | ONO-7018 | Preclinical - Cell culture | Actionable | In a preclinical study, ONO-7018 inhibited proliferation of a diffuse large B-cell lymphoma cell line expressing BTK C481S in culture (Blood (2023) 142 (Supplement 1): 5779). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| ONO-7018, a First-in-Class MALT1 Inhibitor, Provides Novel Therapeutic Strategies for B Cell Malignancies: Overcoming BTK Inhibitor Acquired Resistance and Enhancing the Antitumor Effect of BTK Inhibitors | Full reference... |