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| Molecular Profile | PTEN loss |
| Therapy | Panulisib |
| Indication/Tumor Type | prostate cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | prostate cancer | sensitive | Panulisib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Panulisib (P7170) inhibited tumor growth in PTEN null prostate cancer cell xenograft models (PMID: 25700704). | 25700704 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25700704) | P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity. | Full reference... |