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| Molecular Profile | BRAF G466E HRAS G13R |
| Therapy | Trametinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF G466E HRAS G13R | Advanced Solid Tumor | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, HRAS-null, NRAS-null, and KRAS knockout cells expressing HRAS G13R and BRAF G466E were sensitive to Mekinist (trametinib) in culture, demonstrating decreased cell viability (PMID: 39152269). | 39152269 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39152269) | Cooperative genomic lesions in HRAS-mutant cancers predict resistance to farnesyltransferase inhibitors. | Full reference... |