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Molecular Profile | KMT2A rearrange |
Therapy | I-CBP112 + JQ1 |
Indication/Tumor Type | leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | leukemia | predicted - sensitive | I-CBP112 + JQ1 | Preclinical | Actionable | In a preclinical study, I-CBP112 sensitized leukemia cells harboring KMT2A fusions to JQ1, resulting in decreased cell growth in culture (PMID: 26552700). | 26552700 |
PubMed Id | Reference Title | Details |
---|---|---|
(26552700) | Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. | Full reference... |