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Molecular Profile | EML4 - ALK ALK T1151M ALK G1202R |
Therapy | Brigatinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK T1151M ALK G1202R | lung non-small cell carcinoma | resistant | Brigatinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, a patient-derived non-small cell lung cancer cell line harboring EML4-ALK, ALK G1202R, and ALK T1151M was resistant to Alunbrig (brigatinib) treatment in culture (PMID: 39269178). | 39269178 |
EML4 - ALK ALK T1151M ALK G1202R | lung non-small cell carcinoma | resistant | Brigatinib | Case Reports/Case Series | Actionable | In a clinical case study, Alunbrig (brigatinib) treatment resulted in a partial response lasting 10 months in a patient with non-small cell lung cancer harboring EML4-ALK with ALK G1202R and ALK T1151M (PMID: 39363320; NCT02517892). | 39363320 |
PubMed Id | Reference Title | Details |
---|---|---|
(39269178) | NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. | Full reference... |
(39363320) | Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development. | Full reference... |