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Molecular Profile | PTEN loss |
Therapy | MK2206 |
Indication/Tumor Type | prostate cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | prostate cancer | no benefit | MK2206 | Phase I | Actionable | In a Phase I clinical trial, 8 patients with metastatic, castration-resistant prostate cancer harboring a loss of PTEN did not respond to MK-2206 therapy, but prolonged stable disease was observed in 2 patients (PMID: 26187616). | 26187616 |
PubMed Id | Reference Title | Details |
---|---|---|
(26187616) | A Phase I Trial of Combined Ridaforolimus and MK-2206 in Patients with Advanced Malignancies. | Full reference... |