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Molecular Profile | BRAF V600E |
Therapy | Trametinib |
Indication/Tumor Type | diffuse leptomeningeal glioneuronal tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | diffuse leptomeningeal glioneuronal tumor | predicted - sensitive | Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, Mekinist (trametinib) treatment resulted in a partial response in the brain and stable disease in the spine in a pediatric patient with diffuse leptomeningeal glioneuronal tumor harboring BRAF V600E (PMID: 39399174). | 39399174 |
PubMed Id | Reference Title | Details |
---|---|---|
(39399174) | BRAF/MEK inhibitors use for pediatric gliomas; real world experience from a resource-limited country. | Full reference... |