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| Molecular Profile | TP53 wild-type |
| Therapy | BI 907828 |
| Indication/Tumor Type | liposarcoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 wild-type | liposarcoma | sensitive | BI 907828 | Preclinical - Cell culture | Actionable | In a preclinical study, BI 907828 inhibited viability of TP53 wild-type liposarcoma cell lines in culture (PMID: 39259562). | 39259562 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39259562) | Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules. | Full reference... |