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| Molecular Profile | MDM2 amp TP53 wild-type |
| Therapy | BI 907828 |
| Indication/Tumor Type | intrahepatic cholangiocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 amp TP53 wild-type | intrahepatic cholangiocarcinoma | predicted - sensitive | BI 907828 | Case Reports/Case Series | Actionable | In a Phase Ia/Ib trial, BI 907828 treatment resulted in a partial response in a patient with MDM2-amplified (CN=9), TP53 wild-type metastatic intrahepatic cholangiocarcinoma, with treatment lasting 12 months (PMID: 38567193; NCT03449381). | 38567193 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38567193) | Efficacy and Safety of the MDM2-p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced Biliary Tract Cancer: A Case Series. | Full reference... |