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Molecular Profile | ARID1A inact mut |
Therapy | HM97662 |
Indication/Tumor Type | urinary bladder cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A inact mut | urinary bladder cancer | predicted - sensitive | HM97662 | Preclinical | Actionable | In a preclinical study, HM97662 treatment inhibited tumor growth in a xenograft model of bladder cancer harboring an ARID1A loss-of-function mutation (Cancer Res (2024) 84 (6_Supplement): 3240). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 3240: Synthetic lethal strategy of an EZH1/2 dual inhibitor, HM97662, for the treatment of ARID1A-mutated solid cancers | Full reference... |