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Molecular Profile BRAF V600E
Therapy Binimetinib + Cetuximab + Encorafenib
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E pancreatic ductal adenocarcinoma predicted - sensitive Binimetinib + Cetuximab + Encorafenib Case Reports/Case Series Actionable In a clinical case study, third-line treatment with the combination of Mektovi (binimetinib), Erbitux (cetuximab), and Braftovi (encorafenib) resulted in a partial response with a 74% decrease in primary tumor size in a patient with metastatic pancreatic ductal adenocarcinoma harboring BRAF V600E (PMID: 39461261). 39461261
PubMed Id Reference Title Details
(39461261) Encorafenib, binimetinib and cetuximab in BRAF V600E-mutated advanced pancreatic adenocarcinoma. Full reference...