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Molecular Profile | FLT3 exon 14 ins |
Therapy | Dubermatinib + Gilteritinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Dubermatinib + Gilteritinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with the combination of Dubermatinib (TP-0903) and Xospata (gilteritinib) inhibited proliferation and synergistically induced apoptosis in an acute myeloid leukemia cell line and in patient-derived cells harboring a FLT3-ITD in culture, and led to a greater decrease in leukemic burden and improved survival compared to treatment with either agent alone in a cell line xenograft model (PMID: 39395205). | 39395205 |
PubMed Id | Reference Title | Details |
---|---|---|
(39395205) | Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia. | Full reference... |