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Molecular Profile FLT3 exon 14 ins
Therapy Dubermatinib + Sorafenib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins acute myeloid leukemia sensitive Dubermatinib + Sorafenib Preclinical - Cell culture Actionable In a preclinical study, treatment with the combination of Dubermatinib (TP-0903) and Nexavar (sorafenib) inhibited proliferation of an acute myeloid leukemia cell line harboring a FLT3-ITD in culture (PMID: 39395205). 39395205
PubMed Id Reference Title Details
(39395205) Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia. Full reference...