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Molecular Profile | FGFR2 amp |
Therapy | Pemigatinib |
Indication/Tumor Type | stomach cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | stomach cancer | sensitive | Pemigatinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Pemazyre (pemigatinib) inhibited viability in a gastric cancer cell line with FGFR2 amplification in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 32315352). | 32315352 |
PubMed Id | Reference Title | Details |
---|---|---|
(32315352) | INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models. | Full reference... |