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Molecular Profile | CTNNB1 mutant |
Therapy | PMED-1 |
Indication/Tumor Type | hepatocellular carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CTNNB1 mutant | hepatocellular carcinoma | sensitive | PMED-1 | Preclinical | Actionable | In a preclinical study, PMED-1 decreased Wnt expression and decreased proliferation of hepatocellular carcinoma cells with Ctnnb1 mutations (PMID: 24819961). | 24819961 |
PubMed Id | Reference Title | Details |
---|---|---|
(24819961) | Identification and characterization of a novel small-molecule inhibitor of β-catenin signaling. | Full reference... |