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Molecular Profile | HRAS G12S |
Therapy | Cisplatin + Pemetrexed Disodium + Trametinib |
Indication/Tumor Type | lung squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS G12S | lung squamous cell carcinoma | sensitive | Cisplatin + Pemetrexed Disodium + Trametinib | Preclinical - Pdx | Actionable | In a preclinical study, the addition of Mekinist (trametinib) to treament with the combination of Alimta (pemetrexed disodium) and Platinol (cisplatin) resulted in improved tumor growth inhibition compared to chemotherapy or Mekinist (trametinib) alone in a patient-derived xenograft (PDX) model of squamous non-small cell lung cancer harboring HRAS G12S (PMID: 39199558). | 39199558 |
PubMed Id | Reference Title | Details |
---|---|---|
(39199558) | Evaluation of Combined Chemotherapy and Genomic-Driven Targeted Therapy in Patient-Derived Xenografts Identifies New Therapeutic Approaches in Squamous Non-Small-Cell Lung Cancer Patients. | Full reference... |