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Molecular Profile HRAS G12S
Therapy Buparlisib + Carboplatin + Paclitaxel
Indication/Tumor Type lung squamous cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G12S lung squamous cell carcinoma sensitive Buparlisib + Carboplatin + Paclitaxel Preclinical - Pdx Actionable In a preclinical study, the addition of Buparlisib (BKM120) to treatment with the combination of Paraplatin (carboplatin) and Taxol (paclitaxel) resulted in improved tumor growth inhibition compared to chemotherapy or Buparlisib (BKM120) alone in a patient-derived xenograft (PDX) model of squamous non-small cell lung cancer harboring HRAS G12S (PMID: 39199558). 39199558
PubMed Id Reference Title Details
(39199558) Evaluation of Combined Chemotherapy and Genomic-Driven Targeted Therapy in Patient-Derived Xenografts Identifies New Therapeutic Approaches in Squamous Non-Small-Cell Lung Cancer Patients. Full reference...