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Molecular Profile | CDK12 V387* |
Therapy | Rucaparib |
Indication/Tumor Type | prostate cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDK12 V387* | prostate cancer | sensitive | Rucaparib | Preclinical - Cell culture | Actionable | In a preclinical study, Rubraca (rucaparib) treatment inhibited viability of a CDK12 knockout prostate cancer cell line expressing CDK12 V387* in culture (PMID: 39321214). | 39321214 |
PubMed Id | Reference Title | Details |
---|---|---|
(39321214) | Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors. | Full reference... |