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Molecular Profile | NRAS Q61K |
Therapy | Palbociclib + Trametinib |
Indication/Tumor Type | fibrosarcoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS Q61K | fibrosarcoma | sensitive | Palbociclib + Trametinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Mekinist (trametinib) and Ibrance (palbociclib) combination treatment synergistically inhibited proliferation and induced cell cycle arrest of a fibrosarcoma cell line harboring NRAS Q61K in culture and inhibited tumor growth in a cell line xenograft model (PMID: 39148328). | 39148328 |
PubMed Id | Reference Title | Details |
---|---|---|
(39148328) | Separable Cell Cycle Arrest and Immune Response Elicited through Pharmacological CDK4/6 and MEK Inhibition in RASmut Disease Models. | Full reference... |