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| Molecular Profile | BRAF V600E |
| Therapy | Vemurafenib |
| Indication/Tumor Type | colon cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colon cancer | resistant | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, mouse colon cancer organoids harboring BRAF V600E were resistant to Zelboraf (vemurafenib) in culture (PMID: 39626159). | 39626159 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39626159) | Evolution of Rapid Clonal Dynamics and Non-Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer. | Full reference... |