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Molecular Profile | CDK12 dec exp |
Therapy | Talazoparib |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDK12 dec exp | breast cancer | sensitive | Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, Talzenna (talazoparib) treatment inhibited viability of a breast cancer cell line with decreased CDK12 expression in culture (PMID: 39321214). | 39321214 |
PubMed Id | Reference Title | Details |
---|---|---|
(39321214) | Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors. | Full reference... |