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Molecular Profile ALK F1174C
Therapy Alectinib
Indication/Tumor Type prostate small cell carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1174C prostate small cell carcinoma predicted - sensitive Alectinib Case Reports/Case Series Actionable In a clinical case report, Alecensa (alectinib) treatment in a patient with prostate small cell carcinoma harboring ALK F1174C resulted in stable disease and a decrease in ALK F1174C allele fraction in circulating tumor DNA, with clinical benefit ongoing after 7 months (PMID: 29559559). 29559559
PubMed Id Reference Title Details
(29559559) Anaplastic Lymphoma Kinase Mutation (ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib. Full reference...