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| Molecular Profile | NTRK2 positive |
| Therapy | AZD7451 |
| Indication/Tumor Type | pulmonary large cell neuroendocrine carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK2 positive | pulmonary large cell neuroendocrine carcinoma | sensitive | AZD7451 | Preclinical | Actionable | In a preclinical study, AZD7451 treatment inhibited proliferation of a lung large-cell neuroendocrine carcinoma cell line expressing Ntrk2 in culture (PMID: 25054037). | 25054037 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25054037) | Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro. | Full reference... |