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| Molecular Profile | FGFR2 C382R FGFR2 M538I FGFR2 N550D FGFR2 V565I |
| Therapy | Tinengotinib |
| Indication/Tumor Type | intrahepatic cholangiocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 C382R FGFR2 M538I FGFR2 N550D FGFR2 V565I | intrahepatic cholangiocarcinoma | predicted - sensitive | Tinengotinib | Case Reports/Case Series | Actionable | In a clinical case study, Tinengotinib (TT-00420) treatment resulted in 37% tumor shrinkage in a patient with intrahepatic cholangiocarcinoma harboring FGFR2 C382R, N550D, V565I, and M538I (PMID: 39706336). | 39706336 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39706336) | A Model for Decoding Resistance in Precision Oncology: Acquired Resistance to FGFR inhibitors in Cholangiocarcinoma. | Full reference... |