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Molecular Profile NTRK1 fusion
Therapy Larotrectinib
Indication/Tumor Type spindle cell sarcoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 fusion spindle cell sarcoma predicted - sensitive Larotrectinib Case Reports/Case Series Actionable In a Phase II trial (ADVL1823), first-line Vitrakvi (larotrectinib) treatment resulted in an objective response rate of 60% (9/15), 2-year event-free survival of 80%, and 2-year overall survival rate of 93.3% in patients with NTRK-rearranged solid tumors, including 5 partial responses in 7 patients with spindle cell neoplasm harboring NTRK1 fusion (n=4) or NTRK3 fusion (n=3) (PMID: 39652801; NCT03834961). 39652801
PubMed Id Reference Title Details
(39652801) Larotrectinib for Newly Diagnosed Infantile Fibrosarcoma and Other Pediatric NTRK Fusion-Positive Solid Tumors (Children's Oncology Group ADVL1823). Full reference...