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| Molecular Profile | FGFR1 amp |
| Therapy | Derazantinib |
| Indication/Tumor Type | adrenocortical carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 amp | adrenocortical carcinoma | sensitive | Derazantinib | Phase I | Actionable | In a Phase I trial, ARQ 087 treatment resulted in stable disease with a tumor reduction of 20% in an adrenocortical carcinoma patient harboring FGFR1 amplification, who remained on study for 3.5 years (PMID: 28972963; NCT01752920). | 28972963 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28972963) | A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours. | Full reference... |