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| Molecular Profile | BRAF D594G |
| Therapy | Osimertinib |
| Indication/Tumor Type | lung adenocarcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF D594G | lung adenocarcinoma | predicted - sensitive | Osimertinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Tagrisso (osimertinib) inhibited growth of a patient-derived lung adenocarcinoma cell line harboring BRAF D594G in culture (PMID: 39637338). | 39637338 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39637338) | Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Harboring BRAF Class 3 Mutations. | Full reference... |