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Molecular Profile | FGFR1 V561M |
Therapy | FIIN-1 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 V561M | Advanced Solid Tumor | sensitive | FIIN-1 | Preclinical - Biochemical | Actionable | In a preclinical study, FIIN-1 inhibited Fgfr1 autophosphorylation in a human transformed embryonic kidney cell line harboring FGFR1 V561M mutation in culture (PMID: 20338520). | 20338520 |
PubMed Id | Reference Title | Details |
---|---|---|
(20338520) | A structure-guided approach to creating covalent FGFR inhibitors. | Full reference... |