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| Molecular Profile | PTEN loss |
| Therapy | Copanlisib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | Advanced Solid Tumor | no benefit | Copanlisib | Phase II | Actionable | In a Phase II trial (NCI-MATCH subprotocol Z1G), Aliqopa (copanlisib) treatment demonstrated limited efficacy in advanced solid tumor patients with PTEN loss, resulting in an objective response rate of 0% (0/20), stable disease in 35% (7/20) of patients, median progression-free survival (PFS) of 1.8 mo, 6-mo PFS rate of 17.5%, and median overall survival of 13.7 mo (PMID: 39913886; NCT02465060). | 39913886 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39913886) | Phase II Study of Copanlisib in Patients With PTEN Loss: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols Z1G and Z1H. | Full reference... |