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| Molecular Profile | BARD1 G491R |
| Therapy | Cisplatin + Olaparib |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BARD1 G491R | breast cancer | sensitive | Cisplatin + Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, a breast cancer cell line expressing BARD1 G491R was sensitive to treatment with the combination of Platinol (cisplatin) and Lynparza (olaparib) in culture, demonstrating decreased colony formation (PMID: 39387837). | 39387837 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39387837) | Functional Analysis of BARD1 Missense Variants on Homology-Directed Repair in Ovarian and Breast Cancers. | Full reference... |