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| Molecular Profile | PIK3CA E453K |
| Therapy | LY294002 |
| Indication/Tumor Type | breast cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E453K | breast cancer | decreased response | LY294002 | Preclinical - Cell culture | Actionable | In a preclinical study, a breast cancer cell line expressing PIK3CA E453K was less sensitive to LY294002 treatment compared to cells overexpressing wild-type PIK3CA or PIK3CA E418K in culture (PMID: 38909932). | 38909932 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38909932) | Functional characterization of PI3K C2 domain mutations detected in breast cancer circulating tumor cells and metastatic cells. | Full reference... |