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| Molecular Profile | FLT3 exon 14 ins |
| Therapy | Azacitidine + Narazaciclib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Azacitidine + Narazaciclib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, addition of Vidaza (azacitidine) enhanced the anti-tumor activity of Narazaciclib (ON123300) in a cell line xenograft model of acute myeloid leukemia harboring FLT3-ITD (PMID: 38641704). | 38641704 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38641704) | Narazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models. | Full reference... |