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| Molecular Profile | FLT3 exon 14 ins |
| Therapy | IDRX-42 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | sensitive | IDRX-42 | Preclinical - Cell culture | Actionable | In a preclinical study, IDRX-42 inhibited viability of acute myeloid leukemia cell lines harboring FLT3-ITD in culture (PMID: 40018846). | 40018846 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (40018846) | M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer. | Full reference... |