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| Molecular Profile | PIK3CA H1047R |
| Therapy | BBO-10203 |
| Indication/Tumor Type | breast cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047R | breast cancer | predicted - sensitive | BBO-10203 | Preclinical - Biochemical | Actionable | In a preclinical study, BBO-10203 inhibited Akt phosphorylation in a breast cancer cell line harboring PIK3CA H1047R in culture (PMID: 40504949). | 40504949 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (40504949) | BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction. | Full reference... |