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| Molecular Profile | KIT Y553C |
| Therapy | Nilotinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT Y553C | Advanced Solid Tumor | predicted - sensitive | Nilotinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tasigna (nilotinib) treatment inhibited Kit autophosphorylation and viability of cells expressing KIT Y552C (corresponding to Y553C in human) in culture (PMID: 22083669). | 22083669 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22083669) | Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors. | Full reference... |