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| Molecular Profile | BRAF T529N BRAF V600E |
| Therapy | PLX4720 |
| Indication/Tumor Type | melanoma |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF T529N BRAF V600E | melanoma | predicted - resistant | PLX4720 | Preclinical - Cell culture | Actionable | In a preclinical study, PLX4720 inhibited Mek phosphorylation in a melanoma cell line harboring BRAF V600E and BRAF T529N, however, did not inhibit viability in culture (PMID: 24112705). | 24112705 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24112705) | Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. | Full reference... |