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Molecular Profile PTEN mutant
Therapy GSK2636771
Indication/Tumor Type Advanced Solid Tumor
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN mutant Advanced Solid Tumor no benefit GSK2636771 Phase II Actionable In a Phase II trial (MATCH), GSK2636771 treatment did not meet the primary endpoint of objective response in patients with advanced solid tumors harboring PTEN mutation or deletion but retained protein expression, resulting in stable disease in 32% (7/24) of the patients, a median progression-free survival of 1.8 months, and a median overall survival of 7.5 months (PMID: 40865033; NCT02465060). 40865033
PubMed Id Reference Title Details
(40865033) PIK3CB Inhibitor GSK2636771 in Cancers With PTEN Mutation/Deletion or Loss of PTEN Protein Expression: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols N and P. Full reference...