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| Molecular Profile | PIK3CA H1047L |
| Therapy | Alpelisib |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047L | breast cancer | sensitive | Alpelisib | Preclinical - Cell culture | Actionable | In a preclinical study, Alpelisib (BYL719) inhibited survival of transformed breast epithelial cell lines overexpressing PIK3CA H1047L in culture (PMID: 26627007). | 26627007 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26627007) | Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. | Full reference... |